Exosome component 1

PDB rendering based on 2nn6.

Available structures
PDB	2nn6

Identifiers

Symbols

EXOSC1; CGI-108; CSL4; Csl4p; SKI4; Ski4p; hCsl4p; p13

External IDs

OMIM: 606493 MGI: 1913833 HomoloGene: 9359 GeneCards: EXOSC1 Gene

Gene Ontology
Molecular function	• RNA binding • exoribonuclease activity • protein binding
Cellular component	• exosome (RNase complex) • nucleus • nucleolus • cytoplasm • cytosol
Biological process	• nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • rRNA processing • RNA metabolic process • mRNA metabolic process • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
99.19 – 99.21 Mb

Chr 19:
42 – 42.01 Mb

PubMed search

[1]

[2]

3'-5' exoribonuclease CSL4 homolog is an enzyme that in humans is encoded by the EXOSC1 gene.^[1]^[2]^[3]

This gene encodes a core component of the exosome complex. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46.^[3]

Interactions

Exosome component 1 has been shown to interact with Exosome component 5,^[1]^[4] Exosome component 7^[1]^[4] and Exosome component 6.^[4]

References

^ ^a ^b ^c Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (Jan 2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J Mol Biol 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
^ Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (Nov 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186.
^ ^a ^b "Entrez Gene: EXOSC1 exosome component 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51013.
^ ^a ^b ^c Raijmakers, Reinout; Egberts Wilma Vree, van Venrooij Walther J, Pruijn Ger J M (Nov. 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. (England) 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. ISSN 0022-2836. PMID 12419256.

Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310876.
van Hoof A, Staples RR, Baker RE, Parker R (2000). "Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA.". Mol. Cell. Biol. 20 (21): 8230–43. doi:10.1128/MCB.20.21.8230-8243.2000. PMC 86432. PMID 11027292. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86432.
Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome.". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. PMID 11110791.
Brouwer R, Vree Egberts WT, Hengstman GJ, et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome.". Arthritis Res. 4 (2): 134–8. doi:10.1186/ar389. PMC 83843. PMID 11879549. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=83843.
Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442147.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.

PDB gallery

2nn6: Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40

Exosome component 1

Interactions

References

Further reading